Diphenylphosphinoyl-mediated synthesis of ketones.

نویسندگان

  • David J Fox
  • Daniel Sejer Pedersen
  • Stuart Warren
چکیده

alpha-Diphenylphosphinoyl ketones are selectively and sequentially alkylated at the alpha-position. Double lithiation and selective alkylation occurs at the less stabilised gamma-position. Dephosphinoylation of the alkylation products gives ketones. Mono-alkylation is selective, highly crystalline intermediates are formed and a one-pot strategy is possible. The method is ideally suited for the preparation of acid-sensitive ketones.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 4 16  شماره 

صفحات  -

تاریخ انتشار 2006